Thomas Hübschle Selected Research

Pyrogens

5/2009	Molecular aspects of fever and hyperthermia.
1/2006	Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.
10/2003	Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3.
6/2002	Selected contribution: role of IL-6 in LPS-induced nuclear STAT3 translocation in sensory circumventricular organs during fever in rats.

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Thomas Hübschle Research Topics

Disease

14	Fever (Fevers) 06/2012 - 01/2002
12	Inflammation (Inflammations) 01/2020 - 04/2003
5	Body Weight (Weight, Body) 01/2022 - 02/2015
3	Heart Failure 01/2021 - 03/2013
3	Hypothermia 12/2011 - 01/2006
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2019
2	Fibrosis (Cirrhosis) 01/2020 - 09/2012
2	AIDS-Related Complex (ARC) 11/2019 - 05/2007
2	Myocardial Infarction 06/2019 - 01/2016
2	Ischemia 06/2019 - 03/2013
2	Obesity 01/2018 - 09/2002
2	Hyperthermia 05/2009 - 10/2003
1	Weight Loss (Weight Reduction) 01/2022
1	Disease Progression 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Hyperglycemia 01/2021
1	Hyperlipidemias (Hyperlipidemia) 01/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	Hyperphosphatemia 01/2021
1	Ventricular Remodeling 01/2020
1	Hypertrophy 01/2020
1	Left Ventricular Dysfunction 01/2020
1	Gliosis 11/2019
1	Atrial Fibrillation 06/2019
1	Cardiomyopathies (Cardiomyopathy) 06/2019
1	Genetic Risk Score 01/2018
1	Myocardial Ischemia (Ischemic Heart Diseases) 03/2013
1	Infarction (Infarctions) 03/2013
1	Coronary Occlusion 03/2013
1	Reperfusion Injury 03/2013
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2013
1	Neuraminidase deficiency with beta-galactosidase deficiency 03/2013
1	Hypertension (High Blood Pressure) 09/2012
1	Encephalitis (Encephalitis, Rasmussen) 12/2011
1	Heat Stroke (Heatstroke) 05/2009
1	Neointima 05/2008

Drug/Important Bio-Agent (IBA)

12	Interleukin-6 (Interleukin 6)IBA 06/2012 - 01/2002
9	CytokinesIBA 12/2011 - 01/2002
7	LipopolysaccharidesIBA 12/2011 - 01/2002
5	ProstaglandinsIBA 12/2011 - 01/2002
5	Diclofenac (SR 38)FDA LinkGeneric 07/2007 - 01/2002
4	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2012
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2012
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2011 - 04/2003
4	Dinoprostone (PGE2)FDA Link 05/2009 - 10/2003
4	PyrogensIBA 05/2009 - 06/2002
4	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2007 - 04/2003
3	Peptides (Polypeptides)IBA 01/2022 - 01/2018
3	Cathepsin AIBA 01/2020 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2020 - 12/2011
3	salicylhydroxamic acid (SHAM)IBA 11/2019 - 02/2015
3	EnzymesIBA 03/2013 - 05/2009
3	macrophage stimulatory lipopeptide 2IBA 06/2012 - 01/2006
2	Peptide Hydrolases (Proteases)FDA Link 06/2019 - 01/2016
2	Hormones (Hormone)IBA 01/2019 - 11/2008
2	LeptinIBA 11/2008 - 05/2007
2	Carrier Proteins (Binding Protein)IBA 07/2007 - 04/2003
1	Glucagon (Glukagon)FDA Link 01/2022
1	IncretinsIBA 01/2022
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2022
1	Losartan (Cozaar)FDA LinkGeneric 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	CholesterolIBA 01/2021
1	Colesevelam Hydrochloride (Welchol)FDA Link 01/2021
1	Bile Acids and Salts (Bile Acids)IBA 01/2021
1	PolymersIBA 01/2021
1	Angiotensin Receptor AntagonistsIBA 01/2021
1	CollagenIBA 01/2020
1	Superoxide DismutaseIBA 01/2020
1	Collagen Type III (Type III Collagen)IBA 01/2020
1	Superoxides (Superoxide)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 11/2019
1	NeuropeptidesIBA 11/2019
1	uroguanylinIBA 01/2018
1	guanylinIBA 01/2018
1	ProteomeIBA 01/2016
1	CarboxypeptidasesIBA 01/2016
1	lixisenatideIBA 03/2013
1	GalactosidasesIBA 03/2013
1	Neuraminidase (Sialidase)IBA 03/2013
1	SaltsIBA 09/2012
1	ebelactone BIBA 09/2012
1	Biological ProductsIBA 09/2012
1	BradykininIBA 09/2012
1	Atrial Natriuretic Factor (ANF)IBA 09/2012
1	phospholambanIBA 09/2012
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2011
1	parthenolideIBA 12/2011
1	Pharmaceutical PreparationsIBA 05/2009
1	4-fluoro-N-indan-2-yl-benzamideIBA 05/2008
1	2,2- difluorobenzo(1,3)dioxole- 5- carboxylic acid indan-2-ylamideIBA 05/2008

Therapy/Procedure

3	Glycemic Control 01/2022 - 01/2018
3	Gastric Bypass (Roux-en-Y Gastric Bypass) 11/2019 - 01/2018
3	Intraperitoneal Injections 06/2012 - 01/2006
2	Therapeutics 01/2021 - 06/2019
2	Injections 04/2008 - 06/2004
1	Diet Therapy (Therapy, Diet) 11/2019
1	Lasers (Laser) 11/2019
1	Ligation 01/2016
1	Induced Hypothermia 05/2009